Described herein are systems and methods that allow for secure wireless communication between a contact lens system and an accessory device to protect sensitive data and prevent unauthorized access to confidential information. In certain embodiments, tampering attempts by potential attackers are thwarted by using a Physically Unclonable Functions (PUF) circuit that is immune to reverse engineering. In addition, sensors monitor a to-be-protected electronic device to detect tampering attempts and physical attacks to ensure the physical integrity of the communication system.