- Patent Title: Salt forms and polymorphs of (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido)pyridazin-3-yl)-2-fluorobutyl)-N-methyl-1H-1,2,3-triazole-4-carboxamide
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Application No.: US16241596Application Date: 2019-01-07
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Publication No.: US10899740B2Publication Date: 2021-01-26
- Inventor: Philip Jones , Michael J. Soth , Jason P. Burke , Kang Le , Gang Liu
- Applicant: Board of Regents, The University of Texas System
- Applicant Address: US TX Austin
- Assignee: Board of Regents, The University of Texas System
- Current Assignee: Board of Regents, The University of Texas System
- Current Assignee Address: US TX Austin
- Agent Dennis A. Bennett; Cynthia Hathaway; John Desper
- Main IPC: A61K31/501
- IPC: A61K31/501 ; C07D401/14 ; A61K45/06 ; A61P35/00 ; A61K31/337
Abstract:
Disclosed herein is the compound (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido)pyridazin-3-yl)-2-fluorobutyl)-N-methyl-1H-1,2,3-triazole-4-carboxamide, and salt forms and polymorphs thereof demonstrating improved exposure after oral dosing. Methods of inhibition GLS1 activity in a human or animal subject are also provided.
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