A drain plug linkage structure, comprising a pull rod assembly, a driving rod and a drain plug movably fitted in a drain pipe, the driving rod having a front end and a rear end, the front end of the driving rod being inserted from the side of the drain pipe to the drain pipe and connecting with the drain plug, the pull rod assembly comprises a connecting rod and a pull rod connected to each other, wherein one of the driving rod and the connecting rod is provided with a plurality of fixing holes, the other of the driving rod and the connecting rod is provided with a plurality of protruding fixing members, and the fixing members are detachably coupled to the fixing holes. The present invention is provided that the assembly and disassembly of the driving rod and the connecting rod of the present invention are quicker.