An acoustic air data sensing system includes an acoustic transmitter, a plurality of acoustic receivers, and a skin friction sensor. The acoustic transmitter is located to transmit an acoustic signal into airflow about an exterior of a vehicle. Each of the acoustic receivers is located at a respective angle from a wind angle reference line and a respective distance from the acoustic transmitter. The skin fiction sensor is positioned in a boundary layer region of the airflow that interacts with the acoustic receivers and transmitter. Based on time of flight values of the acoustic signal from the transmitter to each of the receivers and a skin friction measurement from the skin friction sensor as inputs to a transformation matrix, the acoustic air data sensing system outputs, from the transformation matrix, the true airspeed, the relative wind angle, and the speed of sound for operational control of the vehicle.