The present disclosure provides a method and a device for responding to a touch operation, belonging to the field of man-machine interface. The method includes the followings. A usage scenario of a mobile terminal is determined. A first touch operation and a second touch operation applied on a touch display screen within a predetermined duration are received. A first operation type of the first touch operation is determined. A second operation type of the second touch operation is determined. It is determined whether to respond to the first touch operation and/or the second touch operation based on the first operation type, the second operation type and the usage scenario.