Systems and methods to detect and neutralize malware infected electronic communications are described. The system may receive a request for interface information from over a network from a client machine. In response to receiving the request the system may generate the interface information to include at least one input mechanism to receive user information from the user and countermeasure information for utilization on the client machine to detect whether the interface information is modified on the client machine to receive user information from the user that is not authorized. Finally, the system may communicate the interface information, over the network, to the client machine.