Invention Grant
- Patent Title: Chimeric hepatitis D virus antigen and hepatitis B virus pre S1 genes for use alone or in vaccines containing hepatitis B virus genes
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Application No.: US16069372Application Date: 2017-01-26
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Publication No.: US10905760B2Publication Date: 2021-02-02
- Inventor: Matti Sällberg , Lars Frelin
- Applicant: Svenska Vaccinfabriken Produktion AB
- Applicant Address: SE Stockholm
- Assignee: Svenska Vaccinfabriken Produktion AB
- Current Assignee: Svenska Vaccinfabriken Produktion AB
- Current Assignee Address: SE Stockholm
- Agency: Knobbe Martens Olson & Bear, LLP
- International Application: PCT/US2017/015064 WO 20170126
- International Announcement: WO2017/132332 WO 20170803
- Main IPC: C07K14/02
- IPC: C07K14/02 ; C07K14/005 ; A61K39/29 ; A61K39/39 ; A61K39/12 ; A61K39/00
Abstract:
Disclosed herein are chimeric genes, compositions of chimeric genes, and compositions of polypeptides that are useful for the generation, enhancement, or improvement of an immune response to a target antigen. Some embodiments of the compositions include chimeric genes encoding hepatitis D antigen (HDAg) protein in combination with one or more self-cleavage 2A polypeptides and a preS 1 polypeptide. In certain embodiments the self-cleavage polypeptide is P2A.
Public/Granted literature
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