Invention Grant
- Patent Title: Methods for screening human blood products comprising plasma using immunocompromised rodent models
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Application No.: US15584685Application Date: 2017-05-02
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Publication No.: US10905779B2Publication Date: 2021-02-02
- Inventor: Steven Braithwaite , Saul A. Villeda , Anton Wyss-Coray
- Applicant: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , U.S. GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS , ALKAHEST, INC.
- Applicant Address: US CA Stanford; US DC Washington; US CA San Carlos
- Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY,U.S. GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS,ALKAHEST, INC.
- Current Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY,U.S. GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS,ALKAHEST, INC.
- Current Assignee Address: US CA Stanford; US DC Washington; US CA San Carlos
- Agency: Casimir Jones, S.C.
- Main IPC: A61K35/16
- IPC: A61K35/16 ; A61K49/00 ; A61K35/12
Abstract:
Methods and compositions are provided for screening candidate compositions for activity with respect to treatment of aging-associated conditions, e.g., cognitive impairment conditions or age-related dementia. Aspects of the methods include administering a human blood product comprising plasma, to an immunocompromised animal, e.g., a mouse or a rat, and measuring the effect of the product on an endpoint, e.g., neurogenesis, locomotor activity, anxiety, spatial memory, and hippocampus-dependent memory.
Public/Granted literature
- US20170232118A1 METHODS FOR SCREENING HUMAN BLOOD PRODUCTS COMPRISING PLASMA USING IMMUNOCOMPROMISED RODENT MODELS Public/Granted day:2017-08-17
Information query
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