Invention Grant
- Patent Title: Fibrinogen-based tissue adhesive patch
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Application No.: US16699773Application Date: 2019-12-02
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Publication No.: US10905792B2Publication Date: 2021-02-02
- Inventor: Orgad Laub , Eran Cohen , Yotam Schwartz
- Applicant: SEALANTIUM MEDICAL LTD.
- Applicant Address: IL Netanya
- Assignee: SEALANTIUM MEDICAL LTD.
- Current Assignee: SEALANTIUM MEDICAL LTD.
- Current Assignee Address: IL Netanya
- Agency: The Roy Gross Law Firm, LLC
- Agent Roy Gross
- Main IPC: A61K9/70
- IPC: A61K9/70 ; A61K38/36 ; A61K38/48 ; A61K33/14 ; A61L15/32 ; A61L15/26 ; A61L15/38 ; A61L15/64

Abstract:
An improved fibrinogen-based tissue sealing patch having a degradation time of less than two weeks is disclosed. The patch comprises a polyethylene glycol-caprolactone-lactide (PEG-CL-LA) triblock copolymer film in which the PEG-CL-LA units are preferably connected by urethane linkages and into a surface of which a fibrinogen-based sealant comprising less than 8 mg/cm2 fibrinogen and less than 10 IU/cm2 thrombin has been incorporated. In preferred embodiments, the polymer film comprises PEG having a molecular weight of between 3000 and 3500 and a CL:LA:PEG ratio of 34:2:1. Methods of production and use of the patch are also disclosed.
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