The present invention discloses a sprayer with self-cleaning function, which includes a tank, a water pump, and a spray device; the water pump, used for conveying the liquid chemical from the tank to the spray device, is provided at its water inlet end with a pipeline switching mechanism to realize the switching between the liquid chemical supply and the water supply. The sprayer with self-cleaning function provided by the present invention is convenient for cleaning the sprayer, prolonging the life of the sprayer.