![Solid forms of (R)-1(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide](/docs/US/2021-02-02/US10906891B2/abs.jpg.600x600.jpg)
- Patent Title: Solid forms of (R)-1(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
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Application No.: US16109931Application Date: 2018-08-23
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Publication No.: US10906891B2Publication Date: 2021-02-02
- Inventor: Ali Keshavarz-Shokri , Beili Zhang , Tim Edward Alcacio , Elaine Chungmin Lee , Yuegang Zhang , Mariusz Krawiec
- Applicant: Vertex Pharmaceuticals Incorporated
- Applicant Address: US MA Boston
- Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee: Vertex Pharmaceuticals Incorporated
- Current Assignee Address: US MA Boston
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Main IPC: C07D405/12
- IPC: C07D405/12 ; A61K45/08 ; A61K31/4709 ; A61K31/47 ; A61K31/404 ; A61K45/06
![Solid forms of (R)-1(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide](/abs-image/US/2021/02/02/US10906891B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith.
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