![Synthetic methods for preparation of (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1,-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate)](/docs/US/2021-02-02/US10906903B2/abs.jpg.600x600.jpg)
- Patent Title: Synthetic methods for preparation of (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1,-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate)
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Application No.: US16929714Application Date: 2020-07-15
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Publication No.: US10906903B2Publication Date: 2021-02-02
- Inventor: Kevin McGee , Bin-Feng Li , Shawn Branum
- Applicant: Neurocrine Biosciences, Inc.
- Applicant Address: US CA San Diego
- Assignee: Neurocrine Biosciences, Inc.
- Current Assignee: Neurocrine Biosciences, Inc.
- Current Assignee Address: US CA San Diego
- Agency: Fish & Richardson P.C.
- Main IPC: C07D471/06
- IPC: C07D471/06 ; A61K31/4745 ; C07D471/04
![Synthetic methods for preparation of (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1,-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate)](/abs-image/US/2021/02/02/US10906903B2/abs.jpg.150x150.jpg)
Abstract:
Provided herein are processes for the preparation of (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate), or a solvate, hydrate, or polymorph thereof.
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