Invention Grant
- Patent Title: Compositions and methods for activating “stimulator of interferon gene”-dependent signalling
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Application No.: US15771286Application Date: 2016-10-28
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Publication No.: US10906930B2Publication Date: 2021-02-02
- Inventor: George Edwin Katibah , David Kanne , Leonard Sung , Kelsey Gauthier , Laura Hix Glickman , Justin Leong , Sarah M. McWhirter , Thomas W. Dubensky, Jr. , Jeffrey McKenna , Stephen M. Canham , Chudi Obioma Ndubaku
- Applicant: ADURO BIOTECH, INC. , NOVARTIS AG
- Applicant Address: US CA Berkeley; CH Basel
- Assignee: ADURO BIOTECH, INC.,NOVARTIS AG
- Current Assignee: ADURO BIOTECH, INC.,NOVARTIS AG
- Current Assignee Address: US CA Berkeley; CH Basel
- Agency: Acuity Law Group, PC
- Agent Michael A. Whittaker
- International Application: PCT/US2016/059506 WO 20161028
- International Announcement: WO2017/075477 WO 20170504
- Main IPC: C07H21/04
- IPC: C07H21/04 ; A61K39/39 ; C07H21/02 ; A61K39/12 ; A61P35/00 ; A61K39/395 ; A61K45/06 ; A61K39/00
Abstract:
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are 2′- or 3′-mono-fluoro substituted, or 2′3′-di-fluoro substituted mixed linkage 2′,5′-3′,5′ CDNs.
Public/Granted literature
- US20190062365A1 COMPOSITIONS AND METHODS FOR ACTIVATING "STIMULATOR OF INTERFERON GENE"-DEPENDENT SIGNALLING Public/Granted day:2019-02-28
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