Invention Grant
- Patent Title: Fusion proteins comprising a binding protein and an interleukin-15 polypeptide having a reduced affinity for IL15Ra and therapeutic uses thereof
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Application No.: US15556282Application Date: 2016-03-07
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Publication No.: US10906952B2Publication Date: 2021-02-02
- Inventor: Jung Gundram , Helmut Salih , Cornelia Lindner , Berit Lochmann
- Applicant: DEUTSCHES KREBSFORSCHUNGSZENTRUM , EBERHARD KARLS UNIVERSITÄT TÜBINGEN
- Applicant Address: DE Heidelberg; DE Tübingen
- Assignee: DEUTSCHES KREBSFORSCHUNGSZENTRUM,EBERHARD KARLS UNIVERSITÄT TÜBINGEN
- Current Assignee: DEUTSCHES KREBSFORSCHUNGSZENTRUM,EBERHARD KARLS UNIVERSITÄT TÜBINGEN
- Current Assignee Address: DE Heidelberg; DE Tübingen
- Priority: EP15157911 20150306
- International Application: PCT/EP2016/054729 WO 20160307
- International Announcement: WO2016/142314 WO 20160915
- Main IPC: C07K14/54
- IPC: C07K14/54 ; C07K16/18 ; C07K16/28 ; C07K16/30 ; C07K19/00 ; A61K38/00
Abstract:
The present invention relates to fusion proteins comprising a binding protein and an IL-15 polypeptide as well as uses thereof, pharmaceutical compositions comprising such fusion proteins and a method for producing such fusion proteins.
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