Invention Grant
- Patent Title: Methods of treatments using chimeric antigen receptors targeting G-protein coupled receptor
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Application No.: US16798151Application Date: 2020-02-21
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Publication No.: US10906956B2Publication Date: 2021-02-02
- Inventor: Renier J. Brentjens , Eric L. Smith , Cheng Liu
- Applicant: MEMORIAL SLOAN KETTERING CANCER CENTER , EUREKA THERAPEUTICS, INC.
- Applicant Address: US NY New York; US CA Emeryville
- Assignee: MEMORIAL SLOAN KETTERING CANCER CENTER,EUREKA THERAPEUTICS, INC.
- Current Assignee: MEMORIAL SLOAN KETTERING CANCER CENTER,EUREKA THERAPEUTICS, INC.
- Current Assignee Address: US NY New York; US CA Emeryville
- Agency: Baker Botts L.L.P.
- Main IPC: C07K14/725
- IPC: C07K14/725 ; C07K16/28
Abstract:
The presently disclosed subject matter provides for methods and compositions for treating multiple myeloma. It relates to chimeric antigen receptors (CARs) that specifically target a G-protein coupled receptor (e.g., a G-protein coupled receptor family C group 5 member D (GPRC5D)), and immunoresponsive cells comprising such CARs. The presently disclosed CARs targeting a G-protein coupled receptor (e.g., GPRC5D) have enhanced immune-activating properties, including anti-tumor activity.
Public/Granted literature
- US20200270328A1 METHODS OF TREATMENTS USING CHIMERIC ANTIGEN RECEPTORS TARGETING G-PROTEIN COUPLED RECEPTOR Public/Granted day:2020-08-27
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