Invention Grant
- Patent Title: Different levels in blood cell samples of EMT-markers for the diagnosis of cancer, in particular of colorectal (CRC) and pancreatic (PC) cancer
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Application No.: US15104129Application Date: 2014-12-16
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Publication No.: US10907210B2Publication Date: 2021-02-02
- Inventor: Luigi Laghi , Giuseppe Celesti
- Applicant: HUMANITAS MIRASOLE S.P.A.
- Applicant Address: IT Rozzano
- Assignee: HUMANITAS MIRASOLE S.P.A.
- Current Assignee: HUMANITAS MIRASOLE S.P.A.
- Current Assignee Address: IT Rozzano
- Agency: Lucas & Mercanti, LLP
- Priority: EP13197367 20131216
- International Application: PCT/EP2014/078095 WO 20141216
- International Announcement: WO2015/091575 WO 20150625
- Main IPC: C12Q1/6886
- IPC: C12Q1/6886
Abstract:
The present invention concerns a method for determining if a subject is affected by a colorectal or pancreatic cancer or for determining the stage and/or the progression of a colorectal cancer. By measuring the presence of a panel of m RNAs encoding for transcription factors/genes involved in epithelial to mesenchymal transition in a blood sample, wherein different mRNA levels of a set of genes comprising TWIST1, SLUG, ZEB2, ZEB1 and CDH1, are indicative of colorectal cancer or pancreatic cancer diagnosis, and/or of colorectal cancer stage at diagnosis, and/or of CRC metastatic progression after surgery. The invention concerns also the use of kits to work the method.
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