A window replacement panel including an air conditioning vent incorporated into it. A window assembly may be attached to a decorative panel with a vent disposed on a first side, and a coupling for an AC duct on an opposite side. The window may be a single, double pane, insulated, uninsulated or the like. The panel may be clad with material to harmonize with the building exterior, and the exterior vent presents a pleasing appearance. The combination of window and panel may be sized to replace an existing window, or may be used in new construction.