A power switch multiplexer with configurable overlap is disclosed. An integrated circuit (IC) includes a first functional circuit block coupled to receive a supply voltage from a first supply voltage node. The IC further includes an input circuit and an output circuit. Responsive to receiving an input signal, the input circuit asserts an activation signal to cause one of a second supply voltage node and a third supply voltage node to be electrically coupled to the first supply voltage node. Subsequently the input circuit asserts a deactivation signal to cause the other one of the second and third supply voltage nodes to be electrically decoupled from the first supply voltage node. The output circuit is coupled to receive the activation signal and the deactivation signal, and configured to assert a first output signal subsequent to receiving the activation signal.