Systems, methods, and machine-readable media are provided for processing of designated items in a facility. In exemplary embodiments, data is received from the scanning of a machine-readable identifier affixed to a first item and that type of item is identified as requiring special handling based on the data and unique criteria derived for the facility. The unique criteria are based at least in part on historical loss data associated with the facility. The item is placed in a secure storage location and one or more images taken by an imaging device of the designated item located in the secure storage location are taken. The images of the designated item in the secure storage location are associated with a record for the designated item in a database.