The present disclosure provides a pixel circuit, a driving method, pixel structure and display panel. A driving unit of the pixel circuit includes an isolating transistor, driving transistor and light emitting control transistor coupled between an external power supply and light emitting unit in series with source and drain electrodes. Both gates of the light emitting control transistor and isolating transistor receive a first control signal, and the driving transistor and compensating transistor are transistors with common gate region. The driving transistor is used to generate a driving current to drive the light emitting unit to emit light when the isolating transistor and light emitting control transistor are turned on under the control of the first control signal, and the driving current is obtained according to the first voltage, a voltage of the external power supply, and a threshold voltage of the driving transistor in the driving unit.