Disclosed herein are memory devices, systems, and methods of content-aware decoding of encoded data. In one aspect, an encoded data chunk is received and one or more characteristics, such as source statistics, are determined. A similar data chunk (that may, e.g., contain data of a similar type) with comparable statistics may be sought. The similar data chunk may, for example, have source statistics that are positively correlated to the source statistics of the encoded data chunk to be decoded. Decoder parameters for the encoded data may be set to correspond with decoder parameters suited to the similar data chunk. The encoded data chunk is decoded using the new decoder parameters. Decoding encoded data based on content can enhance performance, reducing decoding latency and/or power consumption.