A mechanism to help avoid operational failures with respect to mobile network operator (MNO) service profiles on embedded universal integrated circuit cards (eUICCs). A profile management system or other entity detects operational failures associated with MNO service profiles and responsively provides new MNO service profiles selected to help avoid recurrence of the operational failures. For instance, the profile management system could detect an operational failure that occurred on a given mobile device and could responsively provide a replacement MNO service profile for installation on that device. Further, the profile management system could detect a trend where such failures occur with respect to MNO service profiles from a first source (e.g., first vendor) on eUICCs from a second source (e.g., a second vendor) and could responsively take action to help avoid such a combination of MNO service profile and eUICC, so as to help avoid recurrence of the operational failures.