The present invention relates to a mobile phone case and, more specifically, to a mobile phone case having make-up palettes capable of being separated and combined, in which the mobile phone case is provided, on the rear surface thereof, with a cosmetics storage recess for storing a plurality of make-up palettes capable of being combined in various ways, which enables a user to: select and combine different colored make-up palettes according to a user selection, thereby solving an inconvenience to separately carry various types of cosmetics and make-up kits; freely configure make-up palettes to reflect the user's individuality and preference; and change only a necessary module, which is rational and economical in that the user does not need to newly purchase all make-up palettes in order to use one type of cosmetics.