Invention Grant
- Patent Title: Carrier for use in delivering drug, conjugate, composition comprising same, and method for administrating same
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Application No.: US15902255Application Date: 2018-02-22
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Publication No.: US10912838B2Publication Date: 2021-02-09
- Inventor: Kazunori Kataoka , Yasutaka Anraku , Nobuhiro Nishiyama , Kanjiro Miyata , Takehiko Ishii , Yu Matsumoto , Yu Fukusato , Akihiro Mizoguchi , Takanori Yokota , Hiroya Kuwahara , Kazutaka Nishina , Hidehiro Mizusawa
- Applicant: THE UNIVERSITY OF TOKYO , NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
- Applicant Address: JP Bunkyo-ku; JP Bunkyo-ku
- Assignee: THE UNIVERSITY OF TOKYO,NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
- Current Assignee: THE UNIVERSITY OF TOKYO,NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY
- Current Assignee Address: JP Bunkyo-ku; JP Bunkyo-ku
- Agency: Oblon, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2013-242347 20131122,JP2014-096935 20140508
- Main IPC: A61K47/60
- IPC: A61K47/60 ; A61K9/127 ; A61K31/7088 ; B01J13/02 ; A61K47/54 ; C08G81/00 ; C08G69/10 ; C08G69/40 ; C07K16/00 ; A61K47/64 ; A61K47/69 ; A61K9/00 ; A61K39/44 ; A61K39/00
Abstract:
The present invention provides a vesicle, a conjugate, a composition comprising the vesicle or the conjugate, for use in delivering a drug to the brain, and a method for administering the same. The composition of the present invention is a composition for administration to a subject according to a dosing regimen, comprising a carrier for drug delivery, wherein the dosing regimen comprises administering the composition to a subject who has been fasted or caused to have hypoglycemia and inducing an increase in blood glucose level in the subject, and the carrier is modified at the outer surface thereof with a GLUT1 ligand.
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Information query
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