Invention Grant
- Patent Title: Deuterium substituted positron emission tomography (PET) imaging agents and their pharmacological application
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Application No.: US15994474Application Date: 2018-05-31
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Publication No.: US10912849B2Publication Date: 2021-02-09
- Inventor: Zehui Wu , Zhihao Zha , Futao Liu , Karl Ploessl , Seok Rye Choi , Hank F. Kung
- Applicant: Five Eleven Pharma Inc.
- Applicant Address: US PA Philadelphia
- Assignee: Five Eleven Pharma Inc.
- Current Assignee: Five Eleven Pharma Inc.
- Current Assignee Address: US PA Philadelphia
- Agency: Sterne, Kessler, Goldstein & Fox, P.L.L.C.
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61M36/14 ; A61K51/04 ; A61B6/03 ; C07B59/00 ; C07D221/06 ; C07D213/64 ; C07D405/04 ; C07C217/80 ; C07D471/04 ; C07C323/37 ; C07D277/66
Abstract:
The present invention relates to deuterated compounds according to Formula I-A, Formula II-A, Formula II-D, and Formula III-A. These compounds can be used as PET imaging agents for evaluating Parkinson's Disease, Alzheimer Disease, and for determining specific serotonin reuptake inhibitor (SSRIi) activity for treatment of depression. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I-A, Formulae II-A, Formula II-D, or Formula III-A, or a pharmaceutically acceptable salt thereof.
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