A catheterization system for treatment of patients can include a peripherally inserted central catheter comprising a catheter tube joined to an extension leg with a junction and a securement device that fits around a portion of the junction to inhibit movement. The catheter tube can include a taper proximate the junction, the taper transitioning the catheter tube from a larger outer diameter and a larger wall thickness to a smaller outer diameter and a smaller wall thickness. The taper and thicker wall thickness near the junction can help prevent damage to the catheter tube near the junction when bent (e.g., to secure a proximal region of the catheter to a patient's arm). The securement device can configured to fit around an outer diameter of the junction to inhibit movement of the junction when the junction is held in the securement device.