Invention Grant
- Patent Title: Substituted piperidines thiazolyl acetamides as glycosidase inhibitors and uses thereof
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Application No.: US16061988Application Date: 2016-12-14
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Publication No.: US10913733B2Publication Date: 2021-02-09
- Inventor: Ernest J. McEachern , Harold G. Selnick , Yuanxi Zhou
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent J. Eric Thies; John C. Todaro
- International Application: PCT/US2016/066507 WO 20161214
- International Announcement: WO2017/106254 WO 20170622
- Main IPC: A61K31/454
- IPC: A61K31/454 ; C07D417/06 ; C07D417/14 ; C07D409/06
Abstract:
The present invention is directed to thiazolyl piperidine compounds of the general structural formula I: which are inhibitors of O-GlcNAcase. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which O-GlcNAcase is involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which O-GlcNAcase is involved.
Public/Granted literature
- US20180362517A1 GLYCOSIDASE INHIBITORS AND USES THEREOF Public/Granted day:2018-12-20
Information query
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