Invention Grant
- Patent Title: Efficient process for the preparation of sitagliptin through a very effective preparation of the intermediate 2,4,5-trifluorophenylacetic acid
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Application No.: US16619299Application Date: 2018-05-15
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Publication No.: US10913747B2Publication Date: 2021-02-09
- Inventor: Ottorino De Lucchi , Pierluigi Padovan , Elena Brasola
- Applicant: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.
- Applicant Address: IT Montecchio Maggiore
- Assignee: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.
- Current Assignee: F.I.S. - FABBRICA ITALIANA SINTETICI S.P.A.
- Current Assignee Address: IT Montecchio Maggiore
- Agency: Lucas & Mercanti, LLP
- Priority: EP17179524 20170704
- International Application: PCT/EP2018/062508 WO 20180515
- International Announcement: WO2019/007578 WO 20190110
- Main IPC: C07D487/04
- IPC: C07D487/04 ; B01J27/08
Abstract:
Object of the present invention is an efficient process for the preparation of the active pharmaceutical ingredient Sitagliptine and the 2,4,5-trifluorophenylacetic acid (TFAA) and salt thereof, which is a key intermediate for the synthesis of Sitagliptine.
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