Invention Grant
- Patent Title: Oligonucleotides comprising acyclic and abasic nucleosides and analogs
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Application No.: US13642772Application Date: 2011-04-22
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Publication No.: US10913767B2Publication Date: 2021-02-09
- Inventor: Muthiah Manoharan , Kallanthottathil G. Rajeev , Jeremy Lackey , Narayanannair K. Jayaprakash
- Applicant: Muthiah Manoharan , Kallanthottathil G. Rajeev , Jeremy Lackey , Narayanannair K. Jayaprakash
- Applicant Address: US MA Cambridge; US MA Cambridge; US MA Cambridge; US MA Cambridge
- Assignee: Muthiah Manoharan,Kallanthottathil G. Rajeev,Jeremy Lackey,Narayanannair K. Jayaprakash
- Current Assignee: Muthiah Manoharan,Kallanthottathil G. Rajeev,Jeremy Lackey,Narayanannair K. Jayaprakash
- Current Assignee Address: US MA Cambridge; US MA Cambridge; US MA Cambridge; US MA Cambridge
- Agency: Cozen O'Connor
- Agent Jeffrey N. Townes
- International Application: PCT/US2011/033598 WO 20110422
- International Announcement: WO2011/133876 WO 20111027
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/00 ; C07F9/6512 ; C07F9/655 ; C07F9/6558 ; C07H19/20 ; C12N15/11
Abstract:
This invention relates to an oligonucleotide comprising one or more abasic nucleoside monomers of formula V: These monomers are useful for modifying of oligonucleotides at one or more positions. This invention also relates to a method of inhibiting the expression of a target gene in a cell. The method comprises contacting the cell with an oligonucleotide having one or more of the above formula (V).
Public/Granted literature
- US20130130378A1 OLIGONUCLEOTIDES COMPRISING ACYCLIC AND ABASIC NUCLEOSIDES AND ANALOGS Public/Granted day:2013-05-23
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