Invention Grant
- Patent Title: Anti-human papillomavirus 16 E6 T cell receptors
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Application No.: US16408939Application Date: 2019-05-10
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Publication No.: US10913785B2Publication Date: 2021-02-09
- Inventor: Christian S. Hinrichs , Steven A. Rosenberg
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US MD Bethesda
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US MD Bethesda
- Agency: Leydig, Voit & Mayer
- Main IPC: A61K39/12
- IPC: A61K39/12 ; C07K14/725 ; A61K35/17 ; C07K16/28 ; G01N33/566 ; A61K38/00
Abstract:
Disclosed is a T cell receptor (TCR) having antigenic specificity for an HLA-A2-restricted epitope of human papillomavirus (HPV) 16 E6, E629-38. Related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells are also provided. Antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention are also provided. Also disclosed are methods of detecting the presence of a condition in a mammal and methods of treating or preventing a condition in a mammal, wherein the condition is cancer, HPV 16 infection, or HPV-positive premalignancy.
Public/Granted literature
- US20190309043A1 ANTI-HUMAN PAPILLOMAVIRUS 16 E6 T CELL RECEPTORS Public/Granted day:2019-10-10
Information query
