A system and method to determine availability of caregivers to respond to nurse calls or other alerts originating in patient rooms is provided. Caregivers are designated as unavailable depending upon room types in which they are located, or depending upon patient types in the rooms in which they are located, or depending upon how long they have been present in certain rooms, or depending upon whether the caregivers have designated themselves as unavailable, or any combination of the foregoing. A system and method to escalate alerts to other caregivers if a primary caregiver is unavailable includes escalating first to a designated secondary caregiver and then to a caregiver who is closest in proximity to the room from which the alert originated if the secondary caregiver is also unavailable.