A plugging calibration tool is provided. The plugging calibration tool includes a body and a slide clamp assembly. The body includes keying portions, flanges and a calibrator. The slide clamp assembly includes a slide clamp, which is movable between the keying portions and the flanges, and biasing and locking elements. The biasing and locking elements are respectively configured to bias the slide clamp toward and to lock the slide clamp in abutment with a tool head, which is fittable between the keying portions and the slide clamp, such that the tool head engages with the keying portions. A head of a screw engaged with the tool head is receivable in the calibrator and rotatable in the calibrator such that the head of the screw is drawn into abutment with a calibration surface of the calibrator while the tool head engages with the keying portions.