A method, device for switching applications in the split screen mode, and a related device are provided. The method for switching applications in the split screen mode includes: a first selection instruction is received when the split screen mode of a terminal screen is activated by showing a number of display areas, the first selection instruction being configured to select a target display area from the display areas; one or more applications to be switched in the target display area is displayed in response to a receiving of a switching instruction of applications; a second selection instruction is received, the second selection instruction being configured to select a target application from the one or more applications to be switched; and an application displayed in the target display area is switched to the target application.