A display screen having an irregular shape and a display device are provided. The display screen has a contour line defining an active display area. The display screen includes a plurality of repeatedly arranged first light emitting units and a plurality of repeatedly arranged second light emitting units. The number of sub-pixels in the first light emitting units is greater than or equal to the number of sub-pixels in the second light emitting units. The first light emitting units and the second light emitting units with different structures are combined and filled with the contour line of the display screen to define the active display area, and the contour line is fit by different shapes of the first light emitting units and the second light emitting units.