A method and apparatus for assessing image registration. The method comprises obtaining image datasets for the first and second medical images and registration data representing the registration from the first medical image to the second medical image, collating use-case information for the image registration, deriving a set of at least one measurement and assessment criteria therefor based at least partly on the collated use-case information, performing the at least one measurement on at least one of the obtained image datasets and the obtained registration data to derive at least one measurement value, applying the assessment criteria for the at least one measurement to the at least one measurement value to derive at least one assessment result, and outputting an indication of the at least one assessment result.