Invention Grant
- Patent Title: Method for preparing pimavanserin and tartrate thereof by using triphosgene
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Application No.: US16764315Application Date: 2019-07-19
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Publication No.: US10934257B2Publication Date: 2021-03-02
- Inventor: Biao Wang , Qiao Jiang , Bingbing Li , Murong Peng , Weijian Xie
- Applicant: Livzon New North River Pharmaceutical Co., Ltd.
- Applicant Address: CN Qingyuan
- Assignee: Livzon New North River Pharmaceutical Co., Ltd.
- Current Assignee: Livzon New North River Pharmaceutical Co., Ltd.
- Current Assignee Address: CN Qingyuan
- Agent Benjamin Aaron Adler
- Priority: CN201810832308.0 20180726
- International Application: PCT/CN2019/096705 WO 20190719
- International Announcement: WO2020/020064 WO 20200130
- Main IPC: C07D211/98
- IPC: C07D211/98

Abstract:
The present disclosure discloses a method for safely preparing pimavanserin and tartrate thereof by using triphosgene. The synthesis route includes: Raw materials used in the method of the present disclosure are safe and inexpensive, thereby effectively reducing the production costs. The method of the present disclosure has mild reaction conditions, and avoids using phosgene, which is highly toxic and difficult to handle is avoided. Thus, the method is readily implemented industrially.
Public/Granted literature
- US20200369612A1 Method for Safely Preparing Pimavanserin and Tartrate Thereof by Using Triphosgene Public/Granted day:2020-11-26
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