Invention Grant
- Patent Title: Compounds and compositions for inhibiting the activity of SHP2
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Application No.: US16309076Application Date: 2017-06-12
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Publication No.: US10934285B2Publication Date: 2021-03-02
- Inventor: Zhuoliang Chen , Jorge Garcia Fortanet , Rajesh Karki , Matthew J. Lamarche , Dyuti Majumdar , Lawrence Blas Perez , Martin Sendzik , Troy Douglas Smith , Fan Yang , Bing Yu
- Applicant: Novartis AG
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agent Scott W. Reid
- International Application: PCT/IB2017/053469 WO 20170612
- International Announcement: WO2017/216706 WO 20171221
- Main IPC: C07D487/14
- IPC: C07D487/14 ; C07D471/04 ; C07D401/14 ; C07D403/14 ; C07D455/02 ; C07D487/04 ; C07D495/04 ; C07D513/04 ; C07D519/00
Abstract:
The present invention relates to compounds of formula I: in which Y1, Y2, R1, R2 and R3 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.
Public/Granted literature
- US20200002330A1 COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 Public/Granted day:2020-01-02
Information query
