Invention Grant
- Patent Title: Use of gene editing to generate universal TCR re-directed T cells for adoptive immunotherapy
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Application No.: US15951904Application Date: 2018-04-12
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Publication No.: US10934336B2Publication Date: 2021-03-02
- Inventor: Yangbing Zhao , Xiaojun Liu , Wei Pan
- Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Applicant Address: US PA Philadelphia
- Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Current Assignee: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
- Current Assignee Address: US PA Philadelphia
- Agency: Saul Ewing Arnstein & Lehr LLP
- Agent Kathryn Doyle
- Main IPC: C07K14/705
- IPC: C07K14/705 ; A61P35/00 ; A61K31/65 ; A61K35/17 ; C07K14/725 ; C07K19/00 ; A61K38/17
Abstract:
The present invention includes compositions and methods for a modified immune cell or precursor cell thereof comprising an inducible expression system. Also provided are gene edited modified immune cells suitable for T cell therapy. Methods of treatment using modified immune cells of the present invention are also provided.
Public/Granted literature
- US20190055297A1 USE OF GENE EDITING TO GENERATE UNIVERSAL TCR RE-DIRECTED T CELLS FOR ADOPTIVE IMMUNOTHERAPY Public/Granted day:2019-02-21
Information query
