Invention Grant
- Patent Title: Antibodies specific for hyperphosphorylated tau and methods of use thereof
-
Application No.: US16723143Application Date: 2019-12-20
-
Publication No.: US10934348B2Publication Date: 2021-03-02
- Inventor: Jan Torleif Pedersen , Lars Østergaard Pedersen , Justus Claus Alfred Daechsel , Ayodeji Abdur-rasheed Asuni , Nina Helen Rosenqvist , Christiane Volbracht , Lone Helboe , Anders Brandt Elvang , Florence Sotty , Søren Christensen , Jeffrey B. Stavenhagen
- Applicant: H. Lundbeck A/S
- Applicant Address: DK Valby
- Assignee: H. Lundbeck A/S
- Current Assignee: H. Lundbeck A/S
- Current Assignee Address: DK Valby
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: GB1512211 20150713,GB1518375 20151016
- Main IPC: C07K16/18
- IPC: C07K16/18 ; A61K39/395 ; G01N33/68 ; A61K49/00 ; A61K39/00
Abstract:
The present invention relates to a novel class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396), as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer's disease and tauopathies.
Information query
