Invention Grant
- Patent Title: Chimeric antigen receptors based on single domain antibodies and methods of use thereof
-
Application No.: US15751609Application Date: 2016-08-10
-
Publication No.: US10934363B2Publication Date: 2021-03-02
- Inventor: Xiaohu Fan , Chuan-Chu Chou , Qiuchuan Zhuang , Pingyan Wang , Lin Wang , Lei Yang , Jiaying Hao
- Applicant: Legend Biotech USA Inc.
- Applicant Address: US DE New Castle
- Assignee: Legend Biotech USA Inc.
- Current Assignee: Legend Biotech USA Inc.
- Current Assignee Address: US DE New Castle
- Agency: Jones Day
- Priority: CN201510490002.8 20150811,CN201510733585.2 20151102
- International Application: PCT/CN2016/094408 WO 20160810
- International Announcement: WO2017/025038 WO 20170216
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K14/725 ; C07K14/705 ; C07K16/30 ; A61K35/17 ; C12N5/0783 ; C07K19/00 ; C12N5/10 ; C12N15/62 ; C12N15/63
Abstract:
The present application provides single-domain antibodies, and chimeric antigen receptors comprising one or more antigen binding domains each comprising a single-domain antibody. Further provided are engineered immune effector cells (such as T cells) comprising the chimeric antigen receptors. Pharmaceutical compositions, kits and methods of treating cancer are also provided.
Public/Granted literature
- US20180230225A1 CHIMERIC ANTIGEN RECEPTORS BASED ON SINGLE-DOMAIN ANTIBODIES AND METHODS OF USE THEREOF Public/Granted day:2018-08-16
Information query
