Invention Grant
- Patent Title: Use of trinucleotide repeat RNAs to treat cancer
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Application No.: US15899974Application Date: 2018-02-20
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Publication No.: US10934547B2Publication Date: 2021-03-02
- Inventor: Marcus E. Peter , Andrea E. Murmann
- Applicant: Northwestern University
- Applicant Address: US IL Evanston
- Assignee: Northwestern University
- Current Assignee: Northwestern University
- Current Assignee Address: US IL Evanston
- Agency: Quarles & Brady LLP
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61P35/00 ; C12N15/11 ; A61K31/713 ; A61K47/69 ; A61K47/64
Abstract:
Disclosed are compositions and methods related to RNA interference (RNAi) and the use of RNAi active sequence for treating diseases and disorders. Particular disclosed are toxic RNAi active sequences such as siRNA and shRNA for killing cancer cells. The disclosed toxic RNAi active sequences typically include trinucleotide repeats and preferentially target the expression of multiple essential genes for cell survival and/or growth.
Public/Granted literature
- US20180251762A1 USE OF TRINUCLEOTIDE REPEAT RNAs TO TREAT CANCER Public/Granted day:2018-09-06
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