The present invention relates to a method comprising using an acoustic wave in a chromatography system. The present invention also relates to a corresponding system and a corresponding use. The system may comprise a surface acoustic wave assembly, wherein the surface acoustic wave assembly comprises a sender unit comprising a sender transducer for sending an acoustic wave and a detection unit for detecting the acoustic wave, a substrate configured for propagation of the acoustic wave, wherein the sender transducer is connected to the substrate, wherein the substrate comprises a substrate section for propagation of the wave from the sender transducer, wherein this substrate section comprises a substrate surface, wherein the surface acoustic wave assembly further comprises at least one channel for conducting fluid, wherein this channel is partly defined by the substrate surface.