The present disclosure provides an interaction system of three-dimensional space and a method for operating the same, comprising: determining visual field space according to an eye position of an operator and an angle at which the eye is watching, and determining absolute interaction space and relative interaction space according to respective joint positions of the operator and the visual field space, thereby achieving dividing of areas of the space; determining an operation that matches a current action and needs to be performed by the operator on a selected virtual object according to a relationship among the current action of the operator, the virtual object viewed by the operator and the absolute interaction space, such that when the operator makes the corresponding action, the operation matching the action of the operator is performed on the virtual object; outputting the generated corresponding three-dimensional image display signal to a three-dimensional image display device to complete somatosensory interaction of the three-dimensional space.