Embodiments of systems and methods for encoding content for virtual, augmented, or mixed reality (xR) applications in connectivity-constrained environments are described. In some embodiments, an Information Handling System (IHS) may be configured to: receive sensor information from a Head-Mounted Device (HMD) worn by a user during execution of an xR application; calculate, based on the sensor information, a priority of each of a plurality of Regions-of-Interest (ROIs) within one or more images produced by a rendering engine; and indicate the priorities to a video encoder, where the video encoder is configured to use each priority to control at least one of: (a) visual fidelity, or (b) resilience of a corresponding ROI transmitted by the IHS to the HMD in a video signal during execution of the xR application.