There is described a method, data processing apparatus and computer program product for initializing storage protection, the storage protection for enforcing access permission for a region of storage configured in a layout of regions according to at least one security constraint, the method comprising: receiving a set of storage requirements; generating a layout whereby the layout comprises a combination of storage regions that accommodate the storage requirements within the at least one security constraint; and configuring the storage protection according to the generated layout, wherein generating a layout comprises: calculating, for each storage requirement, a list of all storage regions that could accommodate the storage requirement within the at least one security constraint; selecting and testing combinations of storage regions until a selected combination accommodates the storage requirements within the at least one security constraint; and providing the accommodated combination of storage regions as a region layout.