An Information Handling System (IHS) has persistent memory device(s) coupled to a processor. Each memory device includes a first firmware image, version identifying information associated with the first firmware image, and device type identifying information. A firmware interface suite coupled to the processor has a firmware interface that is executed by the processor. The processor responds to identifying a trigger condition for automatic intra-system firmware update of a persistent memory device. The processor accesses the version identifying information and the device type identifying information for a first memory device containing the first firmware image of the persistent memory device(s). The processor associates the device type identifying information with device type information for a second memory device. In response to the first firmware image being different from the second firmware image, the processor selectively replaces the first firmware image on the first memory device with the second firmware image.