Apparatus and methods are disclosed for controlling execution of memory access instructions in a block-based processor architecture using an instruction decoder that decodes instructions having variable numbers of target operands. In one example of the disclosed technology, a block-based processor core includes an instruction decoder configured to decode target operands for an instruction in an instruction block, the instruction being encoded to allow for a variable number of target operands and a control unit configured to send data for at least one of the decoded target operands for an operation performed by the at least one of the cores. In some examples, the instruction indicates target instructions with a vector encoding. In other examples, a variable length format allows for the indication of one or more targets.