In accordance with embodiments of the present disclosure, a method may include responsive to issuance of, by an application executing on a virtual machine of a hypervisor executing on a processor subsystem of an information handling system, an instruction triggering a virtual machine exit of the virtual machine, invoking a virtual machine exit handler of the hypervisor to handle the instruction. The method may also include determining by the virtual machine exit handler whether the instruction has a characteristic indicating that the instruction should be handled by a hardware accelerator device of the information handling system communicatively coupled to the processor subsystem and responsive to determining that the instruction has a characteristic indicating that the instruction should be handled by the hardware accelerator device, offloading by the virtual machine exit handler processing of the instruction to the hardware accelerator device.