A memory scrubbing system includes a persistent memory device coupled to an operating system (OS) and a Basic Input/Output System (BIOS). During a boot process and prior to loading the OS, the BIOS retrieves a known memory location list that identifies known memory locations of uncorrectable errors in the persistent memory device and performs a partial memory scrubbing operation on the known memory locations. The BIOS adds any known memory locations that maintain an uncorrectable error to a memory scrub error list. The BIOS then initiates a full memory scrubbing operation on the persistent memory device, cause the OS to load and enter a runtime environment while the full memory scrubbing operation is being performed, and provides the memory scrub error list to the OS.