An information handling system may include at least one central processing unit (CPU), and a plurality of special-purpose processing units. The information handling system may be configured to: repeatedly monitor amounts of data traffic exchanged between respective pairs of the special-purpose processing units during selected time periods; based on the monitored amounts of data traffic, determine an amount of traffic imbalance for the plurality of special-purpose processing units; and in response to the amount of traffic imbalance exceeding a threshold amount, transmit a notification indicative of the amount of traffic imbalance.